Cisplatin induced acute mesenteric ischaemia: A case report and review of the literature
- Resource Type
- Authors
- Lauren Kennedy; Shivun Khosla; Yasser Abdulaal
- Source
- International Journal of Surgery Case Reports
- Subject
- medicine.medical_specialty
Acute mesenteric ischaemia
CTA, computed tomography angiogram
TTE, transthoracic echocardiogram
AMAE, acute mesenteric arterial embolism
Gastroenterology
Article
Pathogenesis
03 medical and health sciences
0302 clinical medicine
MDT, multidisciplinary meeting
Internal medicine
Case report
medicine
AMAT, acute mesenteric arterial thrombosis
Cisplatin
business.industry
Vascular disease
Head and neck cancer
SMA, superior mesenteric artery
Arterial thrombosis
Cancer
medicine.disease
Thrombosis
LMWH, low molecular weight heparin
Venous thrombosis
030220 oncology & carcinogenesis
UHI, unfractionated heparin infusion
Surgery
ECG, electrocardiogram
Complication
business
030217 neurology & neurosurgery
medicine.drug
- Language
- ISSN
- 2210-2612
Highlights • Arterial thrombosis occurs in 2% of patients having Cisplatin-based chemotherapy. • There is only one previous report detailing mesenteric ischaemia secondary to cisplatin. • The mechanism relating to the development of arterial thrombosis is not understood. • Benefit of prophylactic parenteral anticoagulation during cisplatin chemotherapy is unknown.
Introduction Cisplatin is a platinum-based chemotherapeutic agent, widely used in cancer therapies for numerous solid tumours. It is becoming more recognised that a potentially life-threatening complication of cisplatin is accelerated arterial and venous thrombosis. Presentation of case We describe a case of a 62 year-old with no risk factors for vascular disease who presented with thromboembolic acute mesenteric ischaemia of the small bowel during treatment with cisplatin for head and neck cancer. Discussion We review the literature on the incidence and pathogenesis of cisplatin induced arterial thrombosis and discuss current treatment options of acute mesenteric ischaemia detailing our management of this case. Conclusion Cisplatin increases the risk of arterial thrombosis and this case report details acute mesenteric ischaemia secondary to its use. We hope to raise clinician awareness of this sequelae which can occur even in patients in the absence of other identifiable risk factors.