Discovery of imatinib-responsive FIP1L1-PDGFRA mutation during refractory acute myeloid leukemia transformation of chronic myelomonocytic leukemia
- Resource Type
- Authors
- Shilpan Shah; Sanam Loghavi; Joseph D. Khoury; Guillermo Garcia-Manero
- Source
- Journal of Hematology & Oncology
- Subject
- Male
Cancer Research
Myeloid
Receptor, Platelet-Derived Growth Factor alpha
Oncogene Proteins, Fusion
Chronic myelomonocytic leukemia
Case Report
PDGFRA
Piperazines
hemic and lymphatic diseases
Eosinophilia
medicine
Humans
Molecular Biology
mRNA Cleavage and Polyadenylation Factors
business.industry
Myeloid leukemia
Imatinib
Leukemia, Myelomonocytic, Chronic
Hematology
Middle Aged
medicine.disease
digestive system diseases
Leukemia
Leukemia, Myeloid, Acute
Imatinib mesylate
medicine.anatomical_structure
Pyrimidines
Treatment Outcome
FIP1L1-PDGRFA
Oncology
Benzamides
Mutation
Cancer research
business
medicine.drug
Chronic myelogenous leukemia
- Language
- ISSN
- 1756-8722
The FIP1L1-PDGFRA rearrangement results in constitutive activation of the tyrosine kinase PDGFRA. Neoplasms harboring this rearrangement are responsive to imatinib mesylate at doses much lower than those recommended for the treatment of chronic myelogenous leukemia. Only a single report has described the identification of FIP1L1-PDGFRA in chronic myelomonocytic leukemia (CMML). Herein, we present a case report of a patient in whom the FIP1L1-PDGFRA was discovered as he evolved from CMML to acute myeloid leukemia (AML). The presence of a dominant neoplastic clone with FIP1L1-PDGFRA rearrangement was suspected on the basis of sudden onset of peripheral and bone marrow eosinophilia and confirmed by fluorescence in situ hybridization and molecular diagnostic tests. Whereas the patient was initially refractory to chemotherapy before the rearrangement was detected, subsequent therapy with imatinib led to complete remission.