Acyltransferase Domain Swapping for the Production of Tenvermectin B Metabolites in Genetically Engineered Strain
- Resource Type
- Authors
- Hui, Zhang; Shaoyong, Zhang; Ji, Zhang; Huan, Qi; Han, Wang; Liqin, Zhang; Jun, Huang; Jidong, Wang
- Source
- Journal of agricultural and food chemistry. 70(38)
- Subject
- Insecticides
Lactones
Ivermectin
Macrocyclic Compounds
Molecular Structure
Acaricides
Acyltransferases
Streptomyces
- Language
- ISSN
- 1520-5118
Tenvermectins A and B (TVMs A and B) are hybrid natural compounds of avermectins and milbemycins with enhanced insecticidal activity. Aiming at obtaining a strain for the production of the higher activity metabolite-TVM-B as a major constituent, a recombinant strain