IntroductionTherapeutic commitment of general nurses influences their provision ofmental health care to clients. It is the general nurses’ predisposition forworking therapeutically with clients who have mental health problems (MHPs). In Malawi, general nurses are the majority of health care professionals who care for people living with HIV/AIDS (PLWHA) and theyare expected to deal with the mental health problems of these patients.The provision of mental health care to PLWHA is vital because apart from the physical illnesses associated with the virus, these people are also affected by mental health problems. However, most general nurses, feelneither confident nor competent when dealing with the mental health problems of their clients in Malawi. This may negatively influence their therapeutic commitment in dealing with mental health problems of PLWHA.However, therapeutic commitment of general nurses in providing mental health care to PLWHA in Malawi remains unknown.Materials and MethodsThe study used a quantitative descriptive survey design. a convenientsample comprising of 136 general nurses was used and data was collectedusing Mental Health Problems Perception Questionnaire. Permission touse the tool in this study was granted by Prof. Lauder. Ethical approvalto conduct the study was granted by Ethics Committees at University of KwaZulu Natal and University of Malawi. Data were analysed using Statistical Package for Social Sciences version 15.0.ResultsThe study findings revealed that there is a linear relationship betweengeneral nurses’ levels of knowledge and skills and their therapeutic commitment (r=.40, n=136, p