Warming Up to Oxazole: Noncryogenic Oxazole Metalation and Negishi Coupling Development
- Resource Type
- Authors
- Michael J. Geier; Selcuk Calimsiz; Xiaotian Wang; Luke D. Humphreys; Mark E. Scott
- Source
- Synlett. 30:1776-1781
- Subject
- chemistry.chemical_compound
010405 organic chemistry
Negishi coupling
Metalation
Chemistry
Organic Chemistry
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Zincate
Oxazole
- Language
- ISSN
- 1437-2096
0936-5214
This report details the development of several suitable noncryogenic metalation conditions for the synthesis of oxazole zincate. Subsequent rounds of high-throughput catalyst screening ultimately led to the identification of several suitable Pd sources that can be used for the Negishi coupling of unsubstituted oxazole. The scope and generality for one of the reported conditions is also presented.