Paraoxonase 1 gene polymorphisms, paraoxonase/arylesterase activities and oxidized low-density lipoprotein levels in patients with migraine
- Resource Type
- Authors
- Recep Aygül; Abdulkadir Yildirim; Mutlu Kuyucu; Senol Dane; Sedat Akar; Serap Yildirim
- Source
- Cell Biochemistry and Function. 29:549-554
- Subject
- medicine.medical_specialty
medicine.diagnostic_test
biology
Chemistry
Clinical Biochemistry
Case-control study
Paraoxonase
Cell Biology
General Medicine
medicine.disease
Biochemistry
Arylesterase
Aryldialkylphosphatase
Endocrinology
Internal medicine
Genotype
medicine
biology.protein
lipids (amino acids, peptides, and proteins)
Endothelial dysfunction
Lipid profile
Lipoprotein
- Language
- ISSN
- 0263-6484
The vascular endothelial dysfunction has been implicated in the pathogenesis of migraine. Oxidized low-density lipoprotein (ox-LDL) may impair endothelial function. Paraoxonase-1 (PON-1) prevents oxidative modification of LDL cholesterol (LDL-C). So we investigated serum PON-1 and arylesterase (ARE) activities, PON-1 55 L/M and 192Q/R polymorphisms and the serum lipid profile in patients with migraine. Biochemical parameters and PON-1 polymorphism analyses were assessed in 104 patients with migraine and 86 healthy subjects. Ox-LDL was detected by ELISA, and polymorphisms were determined using PCR-restriction fragment length polymorphism analysis. Patients with migraine had lower PON-1 and ARE activities (p