Failure of systemic oral doxycycline in preventing ocular toxoplasmic retinochoroiditis in French military personnel
- Resource Type
- Authors
- M Delbarre; T Adam; D. Benisty; M Marechal; Sami Saad; Rana Saad; M Berguiga; F Froussart
- Source
- Journal of the Royal Army Medical Corps. 164:122-123
- Subject
- Adult
Male
medicine.medical_specialty
Pediatrics
030231 tropical medicine
Administration, Oral
03 medical and health sciences
0302 clinical medicine
parasitic diseases
medicine
Humans
Treatment Failure
Toxoplasmosis, Ocular
Doxycycline
biology
business.industry
Malaria prophylaxis
Toxoplasma gondii
General Medicine
medicine.disease
biology.organism_classification
Anti-Bacterial Agents
Malaria
Military personnel
Military Personnel
Chorioretinitis
Tropical medicine
030221 ophthalmology & optometry
France
business
Toxoplasmic chorioretinitis
Uveitis
medicine.drug
- Language
- ISSN
- 2052-0468
0035-8665
This paper describes two cases of toxoplasmic chorioretinitis presenting in two French soldiers who had been receiving oral doxycycline for malaria prophylaxis. This is despite the proven effectiveness of oral doxycycline in treating Toxoplasma gondii, the most common cause of this infection. The lack of effectiveness of oral doxycycline in these two cases most likely reflected that the ocular concentration of 100 mg daily doxycycline is too low to treat or prevent Toxoplasmic retinochoroiditis (TC). Clinicians should therefore be aware that soldiers taking prophylactic oral doxycycline are still at risk of developing ocular TC with potentially sight-threatening consequences if not treated adequately.