On the mechanism of action of GTP-transforming enzymes
- Resource Type
- Authors
- Andrew R. Pitt; Colin J. Suckling; Salah Athmani; Colin L. Gibson; Mark J. Dufton
- Source
- Bioorganic & Medicinal Chemistry Letters. 7:779-784
- Subject
- biology
ATP synthase
GTP'
Chemistry
Stereochemistry
GTP cyclohydrolase I
Organic Chemistry
Clinical Biochemistry
Molybdopterin synthase
Pharmaceutical Science
Context (language use)
Biochemistry
Cofactor
Mechanism of action
Drug Discovery
GTP cyclohydrolase II
biology.protein
medicine
Molecular Medicine
medicine.symptom
Molecular Biology
- Language
- ISSN
- 0960-894X
Mechanisms for the ring conversion of GTP into cofactor precursors by GTP cyclohydrolases and molybdopterin synthase are proposed and discussed in the context of the crystal structure of the GTP cyclohydrolase I - 2′-deoxy-GTP complex. The mechanisms suggest that common features of acid-base catalysis may underly the reactions catalysed in all three cases.