Objective:The objective of this scoping review is to examine the extent of literature on the utility and safety of various types of fibrin sealants in plastic surgery. Considerations such as consent, and cost profile will also be reviewed and identified as future research opportunities.Introduction:Since the approval of fibrin sealants in Europe in the 1970s, they have found their niche in various types of surgical operations, and their utility has led to a rise in popularity. However, the clinical applications of fibrin sealants are not fully synthesized, and important ethical and financial considerations are rarely discussed.Inclusion criteria:Studies reporting the application of commercially available fibrin sealants in plastic surgery procedures on humans of all age groups were included in this review. Additionally, published abstracts and all opinion pieces including commentaries and narrative reviews were exempt.Methods:The key information sources that will be searched are the following: Ovid MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews, Embase, Web of Science Core Collection, and LILACS and grey literature sources. There are no limits placed on the searches. Each publication will be screened by two authors, and any conflict in the selection decision will be resolved by a third author to limit bias.