The latent monkeypox outbreak has become the most emergent public health challenge globally. This study was conducted to assess the acceptability, and willingness to take and pay for a hypothetical Monkeypox vaccine among the Vietnamese general public as well as investigate preference for individual vaccine attributes. Published version This work was funded by Vingroup Joint Stock Company (Vingroup JSC), Vingroup and supported by Vingroup Innovation Foundation (VINIF) under project code VINIF.2020.COVID-19.DA03, and ActionAid Vietnam.