Characterization of the early molecular changes in the glomeruli of Cd151
- Resource Type
- Authors
- Crystal, Naudin; Brian, Smith; Danielle R, Bond; Matthew D, Dun; Rodney J, Scott; Leonie K, Ashman; Judith, Weidenhofer; Séverine, Roselli
- Source
- Scientific Reports
- Subject
- Male
Mice, Inbred C57BL
Extracellular Matrix Proteins
Mice
Matrix Metalloproteinase 10
urogenital system
Blotting, Western
Kidney Glomerulus
Animals
Tetraspanin 24
urologic and male genital diseases
Real-Time Polymerase Chain Reaction
Article
- Language
- ISSN
- 2045-2322
In humans and FVB/N mice, loss of functional tetraspanin CD151 is associated with glomerular disease characterised by early onset proteinuria and ultrastructural thickening and splitting of the glomerular basement membrane (GBM). To gain insight into the molecular mechanisms associated with disease development, we characterised the glomerular gene expression profile at an early stage of disease progression in FVB/N Cd151 −/− mice compared to Cd151 +/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151 −/− compared to Cd151 +/+ glomeruli (p