Ex Vivo Model of Ischemic Mitral Regurgitation and Analysis of Adjunctive Papillary Muscle Repair
- Resource Type
- Authors
- Tabitha Bandy-Vizcaino; Yuanjia Zhu; Annabel M. Imbrie-Moore; Y. Joseph Woo; Robert Wilkerson; Matthew H Park
- Source
- Ann Biomed Eng
- Subject
- medicine.medical_specialty
Swine
Biomedical Engineering
Regurgitation (circulation)
Article
Recurrence
Internal medicine
Mitral valve
medicine
Animals
Humans
Cardiac Surgical Procedures
Papillary muscle
Surgical repair
Ischemic mitral regurgitation
business.industry
Biomechanics
Hemodynamics
Mitral Valve Insufficiency
Equipment Design
Papillary Muscles
Dilatation
Disease Models, Animal
medicine.anatomical_structure
Regurgitant fraction
Cardiology
business
Ex vivo
- Language
- English
Ischemic mitral regurgitation (IMR) is particularly challenging to repair with lasting durability due to the complex valvular and subvalvular pathologies resulting from left ventricular dysfunction. Ex vivo simulation is uniquely suited to quantitatively analyze the repair biomechanics, but advancements are needed to model the nuanced IMR disease state. Here we present a novel IMR model featuring a dilation device with precise dilatation control that preserves annular elasticity to enable accurate ex vivo analysis of surgical repair. Coupled with augmented papillary muscle head positioning, the enhanced heart simulator system successfully modeled IMR pre- and post-surgical intervention and enabled the analysis of adjunctive subvalvular papillary muscle repair to alleviate regurgitation recurrence. The model resulted in an increase in regurgitant fraction: 11.6 ± 1.7% to 36.1 ± 4.4% (p