Additional file 1: Figure S1. Flowchart of patient selection from participating ICUs. Table S1. Amount of Missing Data for Each Variable Included in the Analysis. Table S2. Characteristics of Severe Hypothyroidism Patients According to the Presence of a Circulatory Failure at ICU Admission. Table S3. Clinical and Biological Features at ICU Admission according to ICU survival. Table S4. Predictive Patient Factors Associated with 6-month Mortality in Critically ill Adults with Severe Hypothyroidism.