Introduction: Duchenne muscular dystrophy (DMD) is an inherited x-linked dystrophy that affects one in 3500 male live births. In this patients, the commonest cause of death is respiratory failure. The 90% of patients with DMD who do not use ventilatory support die between 16 and 19 years of age, and uncommonly after age 25. In 2006, in Chile was created a national program of ventilated patients, and were incorporated all patients with DMD. Objective: To describe characterization and survival of patients with DMD with non-invasive ventilation in Chile. Methods: A retrospective study was designed. Patients with DMD and non-invasive ventilation during the period 2006-2016 in the national program of ventilated patients were included. We identified all patients with DMD who died by all causes mortality during the period studied. Results: In the period 2006-2016 was incorporated 140 patients. The mean age was 17.4 ± 4.3 years (range 4.3 – 27.4). Twenty-four patients died. The survival mean was 24.0 years (CI95% 22.9-25.1). The mean age of entry to the program was 13.0 ± 3.4 years and the time of permanence in the program was 4.2 ± 2.9 years. The 100% of patients use bilevel positive airway pressure. The patients by range of age was: 0-4 years 0.9%; 5-9 years 2.6%; 10-14 years 24.1%; 15-19 years 44.8%; > 20 years 27.6%. Conclusion: Use of ventilatory support can prolong survival in Chilean patients with DMD.