Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation
- Resource Type
- Authors
- Ugina Shrestha; Manuel F. Varela; Ranjana Kc; Sanath Kumar; Indrika Ranaweera; Sharla R. Barr; Prathusha Kakarla; T. Mark Willmon; Gui-Xin He; Alberto J. Hernandez
- Source
- Infectious Disorders - Drug Targets. 16:28-43
- Subject
- 0301 basic medicine
Microbiology (medical)
030106 microbiology
Drug resistance
Pharmacology
Biology
Microbiology
03 medical and health sciences
Antibiotic resistance
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Membrane Transport Modulators
Escherichia coli
Humans
Molecular Targeted Therapy
Bacteria
Membrane Transport Proteins
Biological Transport
Bacterial Infections
General Medicine
Antimicrobial
Major facilitator superfamily
Anti-Bacterial Agents
Multiple drug resistance
Infectious disease (medical specialty)
Molecular Medicine
Efflux
Genes, MDR
- Language
- ISSN
- 1871-5265
Causative agents of infectious disease that are multidrug resistant bacterial pathogens represent a serious public health concern due to the increasingly difficult nature of achieving efficacious clinical treatments. Of the various acquired and intrinsic antimicrobial agent resistance determinants, integral-membrane multidrug efflux pumps of the major facilitator superfamily constitute a major mechanism of bacterial resistance. The major facilitator superfamily (MFS) encompasses thousands of known related secondary active and passive solute transporters, including multidrug efflux pumps, from bacteria to humans. This review article addresses recent developments involving the targeting by various modulators of bacterial multidrug efflux pumps from the major facilitator superfamily. It is currently of tremendous interest to modulate bacterial multidrug efflux pumps in order to eventually restore the clinical efficacy of therapeutic agents against recalcitrant bacterial infections. Such MFS multidrug efflux pumps are good targets for modulation.