The Effects of Ranibizumab on Surgically Induced Endometriosis in a Rat Model: A Preliminary Study
- Resource Type
- Authors
- Seda Ates; Taner Molla; Ramazan Dansuk; Gokhan Kilic; Nur Buyukpinarbasili; Asli Sevket; Osman Sevket
- Source
- Reproductive Sciences. 20:1224-1229
- Subject
- medicine.medical_specialty
VEGF receptors
Rat model
Endometriosis
Urology
Antibodies, Monoclonal, Humanized
Endometrial tissue
Random Allocation
chemistry.chemical_compound
Abdominal peritoneum
Ranibizumab
medicine
Animals
Rats, Wistar
biology
business.industry
Obstetrics and Gynecology
medicine.disease
Rats
Surgery
Vascular endothelial growth factor
Disease Models, Animal
chemistry
biology.protein
Female
Peritoneum
business
a preliminary study.-, Reproductive sciences (Thousand Oaks, Calif.), cilt.20, ss.1224-9, 2013 [Sevket O., SEVKET A., BUYUKPıNARBASıLı N., MOLLA T., KILIC G., ATES S., DANSUK R., -The effects of ranibizumab on surgically induced endometriosis in a rat model]
medicine.drug
- Language
- ISSN
- 1933-7205
1933-7191
To examine the effect of ranibizumab on surgically induced endometriosis in rat models.Endometrial tissue was implanted onto the abdominal peritoneum of 20 rats that were randomized into 2 groups. The rats in group 1 (n = 9) were given 0.6 mg/kg ranibizumab on the 1st and 14th days after the second operation. The rats in group 2 (control group, n = 9) received no medication. All the rats were observed for a total of 28 days.At the end of the treatment, the mean volume and weight of the explants in group 1 (11.49 ± 6.87 mm(3) and 36.61 ± 17.84 mg) were significantly lower than that of the control group (190.6 ± 177.4 mm(3) and 187.3 ± 174.5 mg; both Ps.01). Mean epithelial histologic scores were significantly lower in group 1 (1.11 ± 0.78) than that of the control group (2.33 ± 0.71; P.01). When compared with the control group, vascular endothelial growth factor (VEGF) immunoreactivities in group 1 showed statistically significant reductions (1.67 ± 0.50; 2.67 ± 0.50; P.01).Ranibizumab has significantly regressed the size of the endometriotic implants and caused atrophy of these lesions in rats by decreasing explant levels of VEGF.