Plasma glucose and tumour necrosis factor-alpha in adult patients with severe falciparum malaria
- Resource Type
- Authors
- B. K. Das; Rina Tripathy; R. Manish
- Source
- Tropical medicineinternational health : TMIH. 8(2)
- Subject
- Adult
Blood Glucose
Male
Pathology
medicine.medical_specialty
Necrosis
Adolescent
Multiple Organ Failure
Population
Malaria, Cerebral
India
Enzyme-Linked Immunosorbent Assay
Gastroenterology
Internal medicine
Blood plasma
medicine
Humans
Prospective Studies
Malaria, Falciparum
education
Prospective cohort study
Aged
Coma
education.field_of_study
biology
Tumor Necrosis Factor-alpha
Organ dysfunction
Public Health, Environmental and Occupational Health
Plasmodium falciparum
Middle Aged
biology.organism_classification
Hypoglycemia
Infectious Diseases
Cerebral Malaria
Parasitology
Female
medicine.symptom
- Language
- ISSN
- 1360-2276
Plasma glucose was assessed in 81 patients with severe falciparum malaria at the time of presentation along with tumour necrosis factor-alpha (TNF-alpha). The lowest plasma glucose value was 3.38 mmol/l and none of the patients had hypoglycaemia at admission. Plasma glucose values were not significantly lower in those with multiple organ dysfunction (MOD) than in patients with single organ dysfunction (cerebral malaria only) and in those who died compared with patients who survived. Conversely, TNF-alpha showed a good correlation with depth of coma and was significantly higher in patients who had MOD and those who died. There was no correlation between plasma glucose and TNF-alpha values.