Aiming at the deficiency of traditional practice teaching, this article puts forward the construction of three-dimensional practice teaching system in engineering specialty of local colleges and universities. The practice teaching system consists of four modules in the horizontal, such as course experiment, integrated design, science and technology innovation and engineering practice, and contains longitudinal four levels that are the norm, integration, innovation and engineering quality. In order to ensure the effective operation of practical system, the system also strengthens the construction of safeguard mechanism in practice teachers team, practice base and teaching quality monitoring system. The practice shows that the three-dimensional practice teaching system can effectively improve students' ability to integrate theory with practice, hands-on practical ability, ability to analyze and solve problems, scientific and technological innovation ability, and is helpful to promote students' employment.