A One-Pot Coupling/Hydrolysis/Condensation Process to Pyrrolo[1,2-a]quinoxaline
- Resource Type
- Authors
- Dawei Ma; Qiliang Yuan
- Source
- The Journal of Organic Chemistry. 73:5159-5162
- Subject
- Molecular Structure
Chemistry
Hydrolysis
Organic Chemistry
Condensation reaction
Catalysis
Coupling (electronics)
chemistry.chemical_compound
Quinoxaline
Quinoxalines
Polymer chemistry
Organic chemistry
Molecule
Pyrroles
Carboxylate
Acetanilide
- Language
- ISSN
- 1520-6904
0022-3263
CuI/L-proline-catalyzed coupling of 2-halotrifluoroacetanilides with pyrrole-2-carboxylate esters in DMSO at 80-90 degrees C followed by in situ hydrolysis at 60 degrees C afforded pyrrolo[1,2-a]quinoxalines. Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products.