ChemInform Abstract: A One-Pot Coupling/Hydrolysis/Condensation Process to Pyrrolo[1,2-a]quinoxaline
- Resource Type
- Authors
- Dawei Ma; Qiliang Yuan
- Source
- ChemInform. 39
- Subject
- Coupling (electronics)
Hydrolysis
chemistry.chemical_compound
Quinoxaline
chemistry
Condensation process
Polymer chemistry
General Medicine
- Language
- ISSN
- 1522-2667
0931-7597
CuI/L-proline-catalyzed coupling of 2-halotrifluoroacetanilides with pyrrole-2-carboxylate esters in DMSO at 80-90 degrees C followed by in situ hydrolysis at 60 degrees C afforded pyrrolo[1,2-a]quinoxalines. Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products.