Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study
- Resource Type
- Authors
- Jianhong Peng; Binyi Xiao; Lingheng Kong; Qiaoqi Sui; Dingxin Liu; Yuan Li; Zhizhong Pan; Jian Zheng; Xue Chao; Pei-Rong Ding; Wu Jiang; Huizhong Zhang; Qingjian Ou; Jinghua Tang
- Source
- BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Cancer
- Subject
- Adult
Male
0301 basic medicine
Oncology
musculoskeletal diseases
Cancer Research
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
lcsh:RC254-282
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
0302 clinical medicine
Surgical oncology
Internal medicine
Biomarkers, Tumor
Tumor Microenvironment
Genetics
medicine
Humans
Aged
Retrospective Studies
business.industry
Liver oligometastases
DKK1
Immune status
Liver Neoplasms
Cancer
Retrospective cohort study
Immunotherapy
Middle Aged
Prognosis
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Survival Rate
030104 developmental biology
030220 oncology & carcinogenesis
Intercellular Signaling Peptides and Proteins
Biomarker (medicine)
Female
Colorectal Neoplasms
business
CD8
Research Article
- Language
- English
- ISSN
- 1471-2407
Background It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear. Methods CRC cases after resection of liver oligometastases were enrolled in Sun Yat-Sen University Cancer Center with intact clinical data. Serum DKK1 was detected by ELISA assay. Immunofluorescent staining examination for CD3 and CD8 in slices were also conducted. Results Among 65 patients included, the recurrence-free survival (RFS) and overall survival (OS) were significantly better in the low serum DKK1 group (RFS: P = 0.021; OS: P = 0.043). DKK1 was overexpressed in stage IV CRC patients in TCGA data. The number of CD8+ tumor-infiltrating lymphocytes (TILs) in invasive margin of CRC liver oligometastases was significantly higher in low serum DKK1 group (P = 0.042). Conclusion Elevated serum DKK1 level was associated with poorer RFS and OS, and less CD8+ TILs in invasive margin in CRC liver oligometastases. DKK1 might serve as a supplementalprognostic factor for clinical risk score and a potential target for immunotherapy.