Buprenorphine – the unique opioid adjuvant in regional anesthesia
- Resource Type
- Authors
- Juliusz Kosel; Michał Tomczyk; Piotr Bobik
- Source
- Expert Review of Clinical Pharmacology. 9:375-383
- Subject
- medicine.drug_class
medicine.medical_treatment
Anesthesia, General
03 medical and health sciences
0302 clinical medicine
Anesthesia, Conduction
030202 anesthesiology
medicine
Animals
Humans
Pharmacology (medical)
Local anesthesia
Anesthetics, Local
General Pharmacology, Toxicology and Pharmaceutics
Intravenous regional anesthesia
business.industry
Local anesthetic
General Medicine
Buprenorphine
Analgesics, Opioid
Clinical trial
Opioid
Regional anesthesia
Anesthesia
business
Adjuvant
030217 neurology & neurosurgery
medicine.drug
- Language
- ISSN
- 1751-2441
1751-2433
Regional anesthesia techniques are commonly used for many surgical procedures alone or as an addition to general anesthesia, because they offer many advantages over general anesthesia. Unfortunately these techniques are partially limited by the time of action of local anesthetics. One of the methods of overcoming this limitation is adding to the local anesthetic solution additional drug--so called adjuvant. Among many adjuvants to local anesthetic drugs tested so far one seems to be particularly interesting--buprenorphine. The aim of this paper is to present pharmacological background for using buprenorphine for regional anesthesia and to review clinical trials of using buprenorphine for all regional anesthesia techniques: spinal and epidural anesthesia, peripheral nerves blocks, local anesthesia and intravenous regional anesthesia.