Additional file 1: Methods. Table S1. Paclitaxel, trastuzumab, and neratinib drug intensity during weekly paclitaxel phase: NSABP FB-7. Table S2. Pathologic complete response (pCR) rates in neoadjuvant HER2+ breast cancer trials: NSABP FB-7. Figure S1. MammaPrint Scores for patients enrolled in NSABP FB-7. Randomized patients were assigned a MammaPrint score based on the propriatory test from Agendia. Figure S2. Intrinsic subtypes differ in residual tumors compared to the pretreatment biopsy: NSABP FB-7.