Prognostic value of pathological tumor regression grade in locally advanced gastric cancer: New perspectives from a single-center experience
- Resource Type
- Authors
- Monica Gualtierotti; Paolo De Martini; Camillo Leonardo Bertoglio; Carmelo Magistro; Michele Mazzola; Annabella Curaba; Pietro Maria Lombardi; Pietro Achilli; Maria Costanza Aquilano; Giovanni Ferrari
- Source
- Journal of surgical oncologyREFERENCES. 123(4)
- Subject
- Oncology
Male
medicine.medical_specialty
medicine.medical_treatment
Adenocarcinoma
Single Center
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
Internal medicine
medicine
Humans
Radical surgery
Stage (cooking)
Lymph node
Aged
Retrospective Studies
Tumor Regression Grade
Chemotherapy
Univariate analysis
business.industry
Cancer
General Medicine
Middle Aged
medicine.disease
Neoadjuvant Therapy
Survival Rate
medicine.anatomical_structure
Treatment Outcome
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Surgery
Female
Neoplasm Grading
business
Follow-Up Studies
- Language
- ISSN
- 1096-9098
BACKGROUND AND OBJECTIVE Perioperative chemotherapy (PC) with radical surgery represents the gold standard of treatment for resectable advanced gastric cancer (GC). The prognostic value of pathological tumor regression grade (TRG) induced by neoadjuvant chemotherapy (NACT) is not clearly established. This study aimed to investigate the correlation between TRG and survival in GC. METHODS Patients affected by advanced GC undergoing PC and radical surgery were considered. TRG was assessed for each patient according to Becker's grading system. The correlation between TRG and survival was investigated. RESULTS One-hundred patients were selected; 25 showed a good response (GR) (TRG 1a/1b), while 75 had a poor response (PR) (TRG 2/3) to NACT. GR patients showed better disease-free survival (DFS) (52 vs. 19 months, p