The COVID-19 pandemic has profoundly affected the conduct of community-based and community-engaged HIV research. Prior to the pandemic, our community-based participatory research partnership was testing ChiCAS, an in-person, group-level behavioral intervention designed to promote uptake of pre-exposure prophylaxis (PrEP), condom use, and medically supervised gender-affirming hormone therapy among Spanish-speaking transgender Latinas who report having sex with men during the past 6 months. However, the pandemic required adaptations to ensure the safe conduct of the ChiCAS intervention trial. In this paper, we describe adaptations to the trial within critical five domains: (1) participant recruitment, (2) screening and enrollment, (3) baseline data collection, (4) intervention implementation, and (5) participant retention for follow-up data collection. Transgender women continue to be disproportionately affected by HIV; therefore, it was essential to find ways to continue important research designed to support their health and wellbeing within the context of the COVID-19 pandemic. These adaptations offer guidance for ongoing and future community-based and community-engaged research during the COVID-19 pandemic and/or potential subsequent pandemics.