Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens
- Resource Type
- Authors
- Pachón Ibáñez, María Eugenia; Docobo Pérez, Fernando; Blanquero Bravo, Rafael; Garnacho Montero, José; Benítez Peña, Sandra; Dimopoulos, George; Rosso Fernández, Clara; Gutiérrez Pizarraya, Antonio; López Cortés, Luis Fernando; Cisneros Herreros, José Miguel
- Source
- idUS. Depósito de Investigación de la Universidad de Sevilla
instname
- Subject
- health services administration
polycyclic compounds
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
health care economics and organizations
- Language
The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in critically ill patients following the administration of a 4.5 MU CMS loading dose follow by 3MU CMS Q8. A population PK model and Monte Carlo simulation were used to calculate the probability of target attainment (PTA) against Acinetobacter baumannii and Pseudomonas aeruginosa by considering a range of MIC values seen in the clinic.