Objective: To discover the impact of topical negative pressure (TNP) on quality of life. Method: An exploratory prospective cohort study was conducted on 26 patients undergoing TNP. The Cardiff Wound Impact Schedule (CWIS), a wound-specific tool, was used to investigate quality-of-life scores before therapy and four weeks after therapy or at wound closure. Wound dimensions were measured at both assessments, and the values for the CWIS domains (physical symptoms, social functioning, well-being and overall quality of life) were investigated using parametric and non-parametric tests. Results: The mean duration of TNP therapy was 3.3 ± 1.7 weeks. Topical negative pressure therapy helped to achieve complete wound closure in 14 patients (54%), and there was a mean reduction in wound surface area from 52.2cm2 (range 4–150) to 26.8cm2 (0–120). While there was no significant change in quality of life in patients whose wounds healed (1 ± 11.9), the physical-functioning domain improved in obese patients (20 ± 21, p