CTLA4 prohibits T cells from cross-dressing
- Resource Type
- Authors
- Noémie Paillon; Claire Hivroz
- Source
- Journal of Experimental Medicine. 220
- Subject
- Immunology
Immunology and Allergy
- Language
- ISSN
- 1540-9538
0022-1007
In this issue of JEM, Xiaozheng Xu et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221391) report that the inhibitory protein CTLA4 internalizes in cis the B7 stimulatory molecules previously “gnawed” by T cells from antigen-presenting cells (APCs) and in doing so prevents stimulatory T–T interactions.