Wilson Disease-Induced Acute Liver Failure (NWI = 13) Salvaged without Liver Transplant by Plasmapheresis
- Resource Type
- Authors
- Nida Mirza; Anupam Sibal; Ravi Bharadwaj; Smita Malhotra
- Source
- Journal of Child Science. 11:e145-e147
- Subject
- medicine.medical_specialty
business.industry
medicine.medical_treatment
Copper metabolism
030232 urology & nephrology
Acute kidney injury
Liver failure
Disease
Liver transplantation
medicine.disease
Gastroenterology
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
Surgery
Plasmapheresis
business
Fulminant liver failure
Coombs negative hemolytic anemia
- Language
- ISSN
- 2474-5871
Wilson disease (WD) is a disorder of copper metabolism resulting in accumulation of copper in vital organs of the human body, predominantly in the liver and the brain. Acute liver failure in WD has a bad prognosis, especially with a score ≥11 in the revised WD prognostic index; emergency liver transplantation is considered the only life-saving option in this scenario. Here, we reported a girl patient with WD-induced liver failure and poor prognostic score who was rescued by plasmapheresis. She also manifested severe Coombs negative hemolytic anemia and acute kidney injury. This case report highlights the utility of an adjunctive modality besides liver transplantation for the management of fulminant liver failure caused by WD.