WOS: 000407732900008 Acute hemorrhagic edema of infancy is a skin limited leukocytoclastic vasculitis occurring in children younger than 2 years old. Although it has an alarming start, it has a good prognosis. The patients may have a story of drug intake, vaccination or infection. Henoch-Schonlein purpura must be considered in differential diagnosis. With well recognition of this rare disease, the family and the physician's concern will be prevented; unnecessary investigations and interventions will be reduced.