Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain
- Resource Type
- Authors
- Andrea Gogos; Nadia Hale; Nadine Brew; S A Ingelse; Flora Y. Wong; David W. Walker; K L Shepherd; M. van den Buuse
- Source
- Journal of Applied Physiology. 129:1431-1438
- Subject
- 0301 basic medicine
medicine.medical_specialty
Physiology
Dopamine
Striatum
Hypoxia ischemia
Receptors, Dopamine
03 medical and health sciences
0302 clinical medicine
Ischemia
Physiology (medical)
Internal medicine
medicine
Animals
Humans
Hypoxia
Fetus
Sheep
business.industry
Dopaminergic
Infant, Newborn
Brain
Dopamine receptor binding
030104 developmental biology
Endocrinology
Hypoxia-Ischemia, Brain
business
Infant, Premature
030217 neurology & neurosurgery
Sheep brain
medicine.drug
- Language
- ISSN
- 1522-1601
8750-7587
Dopamine is often used to treat hypotension in preterm infants who are at risk of hypoxic-ischemic (HI) brain injury due to cerebral hypoperfusion and impaired autoregulation. There is evidence that systemically administered dopamine crosses the preterm blood-brain barrier. However, the effects of exogenous dopamine and cerebral HI on dopaminergic signaling in the immature brain are unknown. We determined the effect of HI and dopamine on D1 and D2 receptor binding and expressions of dopamine transporter (DAT) and tyrosine hydroxylase (TH) in the striatum of the preterm fetal sheep. Fetal sheep (99 days of gestation, term = 147days) were unoperated controls (