Objectives: The main focus of the current study was to compare the two exercise program, segmental stabilization and strengthening of abdominal and trunk muscles on functional disability in adults with chronic low back pain (CLBP). Materials and Methods: In a randomized controlled trial, fifty patients were randomly selected. Group A patients were treated with segmental stabilization and Group B patients were treated by abdominal and trunk muscles strengthening. Results: Patients in Group A showed marked improvement than patients in Group B (>0.05). Group A patients who were treated with segmental stabilization showed more significant results than Group B who were treated with abdominal and trunk muscles strengthening in improving disability and pain in CLBP (>0.05). Conclusion: It is concluded from the study that segmental stabilization in patients with CLBP is a significant treatment outcome on numeric rating pain Scale and Oswestry disability index.