Thymic carcinoma in a child with HIV infection
- Resource Type
- Authors
- Thomas H. Belhorn; Thomas W. McLean; Scott V. Smith; Julie Blatt; Morgan F. McDonald; Lynn A. Fordham; Charles R. Woods
- Source
- Pediatric Blood & Cancer. 49:1004-1007
- Subject
- Male
Oncology
medicine.medical_specialty
Pathology
Lung Neoplasms
Thymoma
Human immunodeficiency virus (HIV)
Antineoplastic Agents
HIV Infections
Thymic cyst
medicine.disease_cause
Piperazines
chemistry.chemical_compound
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
Child
Thymic carcinoma
business.industry
Mesylate
Liver Neoplasms
Remission Induction
Cancer
Thymus Neoplasms
Hematology
medicine.disease
Lymphoma
Pyrimidines
Treatment Outcome
Mediastinal Cyst
chemistry
Benzamides
Pediatrics, Perinatology and Child Health
Disease Progression
Imatinib Mesylate
Sarcoma
Tomography, X-Ray Computed
business
Follow-Up Studies
- Language
- ISSN
- 1545-5017
1545-5009
HIV infection predisposes to cancer during childhood. In addition to the AIDS-defining non-Hodgkin lymphoma (NHL) and Kaposi sarcoma, a range of other lymphoid malignancies and solid tumors have been described. We report the first case of an HIV-positive child with thymic carcinoma in the setting of regressing thymic cysts. The tumor expressed CKIT but failed to respond to imatinab mesylate after a transient response to multiagent chemotherapy. This case extends the spectrum of pediatric malignancy in the setting of HIV and suggests that patients with presumed benign thymic cysts require ongoing surveillance. Pediatr Blood Cancer 2007;49:1004–1007. © 2005 Wiley-Liss, Inc.