This is a scoping review of the literature on vitamin B12 supplementation during SARS-Cov-2 infection. This review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension. Scoping Reviews (PRSMA-ScR) checklist (Tricco et al., 2018). This guideline, developed by expert consensus through a Delphi panel (HUMPHREY-MURTO et al., 2016), has a checklist of 20 essential report items and two optional items, making up an essential part of the methodology of all analyzes of scope. Therefore, compliance with the PRISMA-ScR guideline represents the most current methodological consistency and understanding of research results in scoping reviews (PETERS et al., 2020).