Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): Is it clinically useful?
- Resource Type
- Authors
- Marco Giorgio Baroni; Michela Incani; Efisio Cossu
- Source
- BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-6 (2019)
BMC Endocrine Disorders
- Subject
- medicine.medical_specialty
endocrine system diseases
Debate
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pregnancy
Diabetes mellitus
Glucose Intolerance
Epidemiology
medicine
Humans
030212 general & internal medicine
Autoantibodies
Glucose tolerance test
Type 1 diabetes
lcsh:RC648-665
medicine.diagnostic_test
Obstetrics
business.industry
Diabetes
Autoantibody
nutritional and metabolic diseases
General Medicine
Glucose Tolerance Test
Prognosis
medicine.disease
Gestational diabetes
Diabetes, Gestational
Diabetes Mellitus, Type 1
Metabolism
Female
Blood sugar regulation
business
- Language
- English
Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder in pregnancy, and it is associated with increased risk of morbidity in maternal-fetal outcomes. GDM is also associated with a higher risk to develop diabetes in the future. Diabetes-related autoantibodies (AABs) have been detected in a small percentage (usually less than 10%) of women with gestational diabetes. The prevalence in gestational diabetes of these autoimmune markers of type 1 diabetes (T1D) has been assessed in many studies, together with the risk of progression of AABs-positive GDM towards impaired glucose regulation (IFG or IGT) and overt diabetes after pregancy. The question whether it is necessary to test for T1D autoantibodies in all pregnancies with GDM is still debated. Here we examine the epidemiology of T1D autoantibodies in GDM, their clinical relevance in term of future risk of diabetes or impaired glucose regulation and in term of maternal-fetal outcomes, and discuss when it may be the most appropriate time to search for T1D autoantibodies in women with gestational diabetes.