The Efficacy, Safety, and Outcomes of Brain-responsive Neurostimulation (RNS® System) therapy in older adults
- Resource Type
- Authors
- Dileep Nair; Vineet Punia; Ifrah Zawar; Andreas V. Alexopoulos; Michael Mackow; Balu Krishnan
- Source
- Epilepsia Open
Epilepsia Open, Vol 6, Iss 4, Pp 781-787 (2021)
- Subject
- medicine.medical_specialty
Drug Resistant Epilepsy
Responsive neurostimulation device
medicine.medical_treatment
Deep Brain Stimulation
Epilepsy
Internal medicine
Medicine
Humans
Short Research Article
In patient
RC346-429
Adverse effect
Neurostimulation
older adults
Aged
Retrospective Studies
business.industry
RNS System
Gold standard
Brain
Retrospective cohort study
Middle Aged
medicine.disease
Electrodes, Implanted
Short Research Articles
Neurology
brain‐responsive neurostimulation
epilepsy
Neurology. Diseases of the nervous system
Neurology (clinical)
business
Responsive neurostimulation
- Language
- ISSN
- 2470-9239
Objectives The gold standard for the management of drug‐resistant focal epilepsy (DRE) is resection of epileptogenic zone. However, some patients may not be candidates for resection. Responsive neurostimulation is approved in patients above 18 years of age for such patients. We aimed to investigate whether RNS outcomes and safety varied based on age. Methods We performed a single‐center retrospective cohort study of patients with DRE who were treated with RNS between May 2008 and February 2020. We included patients who had been implanted with RNS for >6 months (N = 55), dividing them into older (N = 11) and younger adults (N = 44) depending on implantation age (≥50 and