The association of allogeneic blood transfusion and the recurrence of hepatic cancer after surgical resection
- Resource Type
- Authors
- H. L. Wu; Y. H. Tai; K. Y. Chang; M. Y. Tsou; Mercedes Susan Mandell
- Source
- AnaesthesiaReferences. 75(4)
- Subject
- Male
medicine.medical_specialty
Blood transfusion
Carcinoma, Hepatocellular
medicine.medical_treatment
Cancer recurrence
Gastroenterology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
030202 anesthesiology
Internal medicine
Medicine
Humans
Blood Transfusion
030212 general & internal medicine
business.industry
Hazard ratio
Liver Neoplasms
Cancer
Middle Aged
medicine.disease
Red blood cell
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Hepatocellular carcinoma
Female
Hepatectomy
Neoplasm Recurrence, Local
business
Allogeneic transfusion
- Language
- ISSN
- 1365-2044
There is conflicting evidence whether allogeneic blood transfusion influences survival or cancer recurrence after resection of hepatocellular cancer. We followed up 1469 patients who had undergone hepatocellular resection for a median (IQR [range]) of 45 (21-78 [0-162]) months, of whom 626 (43%) had had blood transfusion within 7 days of surgery. Both disease-free survival and patient survival were measured using a proportional hazards regression model and inverse probability of treatment weighting. We used restricted cubic splines for the association of the number of packed red blood cell units transfused with cancer recurrence and survival. We found that peri-operative blood transfusion was independently associated with survival and cancer recurrence after resection of hepatocellular carcinoma. Adjusted hazard ratios (95%CI) for the association of blood transfusion with cancer recurrence and all-cause mortality were 1.3 (1.1-1.4) and 1.9 (1.6-2.3), p < 0.001 for both. With more units transfused cancer recurrence was more likely and survival was shorter. The association of the number of transfused units was non-linear for cancer recurrence and linear response for all-cause mortality.