N-substituted benzenesulfonamide compounds: DNA binding properties and molecular docking studies
- Resource Type
- Authors
- Sultan Erkan; Mehmet Tümer; Seyit Ali Güngör; Muhammet Kose
- Source
- Subject
- chemistry.chemical_classification
0303 health sciences
Sulfonamides
Stereochemistry
030303 biophysics
Imine
Binding properties
General Medicine
DNA
Sulfonamide
Molecular Docking Simulation
03 medical and health sciences
chemistry.chemical_compound
Sulfonamide propargyl imine DNA molecular docking
chemistry
Structural Biology
Propargyl
Thermodynamics
Molecular Biology
- Language
- English
Benzenesulfonamide-based imine compounds 5–8 were prepared and screened for their binding properties to the FSdsDNA. The structures of synthesized compounds were elucidated by the spectroscopic and analytical methods. Compounds 5–8 were screened for their interactions with the FSdsDNA. Compound 8 showed the highest binding affinity to the FSdsDNA with intrinsic binding constant of 3.10 × 104 M−1. The compounds caused the quenching of the DNA–EB emission indicating displacement of EB (ethidium bromide) from the FSdsDNA. Finally, the binding interactions between the DNA and binder molecules 5–8 were examined by the molecular docking studies. The compounds locate approximately same region of the minor groove of DNA via hydrogen bonding contacts between the sulfonamide oxygen atoms and the DG10/DG16 nucleotides of DNA. Communicated by Ramaswamy H. Sarma