Free-floating thrombus of the carotid artery with a homozygous methylenetetrahydrofolate reductase gene mutation: a case report
- Resource Type
- Authors
- Omer Cakir; Dilek Kösehan; Mehmet Fatih Alpay; Necmettin Colak; Yunus Nazli
- Source
- Vascular. 21:35-38
- Subject
- Carotid Artery Diseases
Male
medicine.medical_specialty
Duplex ultrasonography
Carotid Artery, Common
Carotid arteries
DNA Mutational Analysis
medicine.disease_cause
Magnetic resonance angiography
Internal medicine
medicine.artery
medicine
Humans
Genetic Predisposition to Disease
Radiology, Nuclear Medicine and imaging
Common carotid artery
Thrombus
Methylenetetrahydrofolate Reductase (NADPH2)
Thrombectomy
Ultrasonography, Doppler, Duplex
Mutation
medicine.diagnostic_test
biology
business.industry
Homozygote
Anticoagulants
Thrombosis
General Medicine
Middle Aged
medicine.disease
Phenotype
Treatment Outcome
Methylenetetrahydrofolate reductase
cardiovascular system
Cardiology
Etiology
biology.protein
Surgery
Cardiology and Cardiovascular Medicine
business
Magnetic Resonance Angiography
- Language
- ISSN
- 1708-539X
1708-5381
Free-floating thrombus (FFT) of the carotid artery is a rare condition of currently unknown etiology. We describe a symptomatic patient with an FFT in the left common carotid artery. A duplex ultrasonography scan showed the presence of a mobile floating thrombus moving in cyclical motion with the cardiac cycles in the left common carotid artery. During emergency surgery, an FFT was seen at this location and removed. No underlying wall defect was seen at the time of surgery. In a genetic screening test, TT homozygous for the methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphisms was detected. The patient recovered uneventfully, with no neurogical events. Lifelong anticoagulant therapy was recommended. An aggressive surgical approach is recommended in the patient to prevent embolic episodes.