This document contains Supplementary Figures S1-S6 as well as their Legends. Specifically, Fig. S1: characterization of the 52 gene signature; Fig. S2: Validation of the 27 DNA repair and cell cycle gene signature; Fig. S3: Analysis of the Murat cohort; Fig. S4: Analysis of the TCGA dataset; Fig. S5: Identification of differentially expressed genes and gene ontology analysis of the G1 and G3 groups; Fig. S6: DNA repair and cell-cycle-based strategies for personalized management of GBM".