Pancreatic neuroendocrine tumors (PanNETs) are usually diagnosed in an advanced stage. Most patients with PanNETs die of metastasis. Vascular endothelial growth factor-A (VEGF-A) is a strong stimulator of angiogenesis and tumor metastasis. We aimed to investigate the effect of MART-10 [19-nor-2α-(3-hydroxypropyl)-1α,25(OH)Migration and invasion assays, western blot, and immunofluorescent staining were applied in this study.VEGF-A increased PanNET cell migration and invasion, which was attenuated by 1α,25(OH)Our data indicate that MART-10 could be deemed a promising drug for PanNET treatment.