GPR55 regulates the responsiveness to, but does not dimerise with, α
- Resource Type
- Authors
- Sarah K, Walsh; Christopher, Lipina; Sheng Y, Ang; Masaaki, Sato; Ling Yeong, Chia; Martina, Kocan; Dana S, Hutchinson; Roger J, Summers; Cherry L, Wainwright
- Source
- Biochemical pharmacology. 188
- Subject
- Male
Mice, Knockout
CHO Cells
Rats
Mice, Inbred C57BL
Rats, Sprague-Dawley
Mice
Cricetulus
Organ Culture Techniques
Animals, Newborn
Pregnancy
Cricetinae
Receptors, Adrenergic, alpha-1
Animals
Female
Adrenergic alpha-1 Receptor Agonists
Protein Multimerization
Receptors, Cannabinoid
Cells, Cultured
- Language
- ISSN
- 1873-2968
Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not been investigated. This study explored the interaction between GPR55 and the alpha 1A-adrenoceptor (α