Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma
- Resource Type
- Authors
- Damian Jaworski; Aleksander Lamkowski; Magdalena Wietlicka-Piszcz; Jakub J. Kaluzny; Przemysław Zabel; Katarzyna Zabel; Martyna Kaluzna
- Source
- PLoS ONE, Vol 15, Iss 7, p e0235571 (2020)
PLoS ONE
- Subject
- Retinal Ganglion Cells
Male
Eye Diseases
genetic structures
Nerve fiber layer
Glaucoma
Cardiovascular Medicine
Diagnostic Radiology
chemistry.chemical_compound
Animal Cells
Medicine and Health Sciences
Medicine
Cardiovascular Imaging
Tomography
Neurons
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Angiography
Ganglion
medicine.anatomical_structure
Female
Anatomy
Cellular Types
Glaucoma, Open-Angle
Tomography, Optical Coherence
Research Article
medicine.medical_specialty
Ganglion Cells
Open angle glaucoma
Imaging Techniques
Ocular Anatomy
Science
Research and Analysis Methods
Retina
Ocular System
Diagnostic Medicine
Ophthalmology
Humans
Aged
business.industry
Biology and Life Sciences
Afferent Neurons
Retinal Vessels
Retinal
Cell Biology
medicine.disease
eye diseases
Capillaries
chemistry
Cellular Neuroscience
Case-Control Studies
Cardiovascular Anatomy
Eyes
Blood Vessels
sense organs
Visual Fields
business
Head
Microperimetry
Neuroscience
- Language
- ISSN
- 1932-6203
Purpose To evaluate the correlation between retinal sensitivity in microperimetry (MP) with vessel density (VD) using optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG). Methods We enrolled 30 participants (52 eyes) with POAG and 15 participants (23 eyes) in the healthy control group. All participants were examined for retinal structure using OCTA to assess VD and Spectral domain OCT (SD-OCT) to assess ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thickness. Retinal sensitivity was tested with MP and standard automatic perimetry (SAP). Results The VD in moderate/severe POAG was lower than that in mild POAG and healthy control in the macular superficial vascular plexus (SVP) (38.7±6.3% vs. 42.9±5.2%, 49.7±2.6% respectively, P0.05). Conclusion The relationship between microvascular damage in the macular SVP whole and the decrease of MP average sensitivity threshold is stronger than the pRNFL thickness measurements and SAP parameters. OCTA and MP techniques are valuable methods that allow clinically monitor structural and functional changes in glaucomatous eyes.