Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction
- Resource Type
- Authors
- Stefan Uhlmann; Roland Veltkamp; Lorenz H. Lehmann; Herrmann-Josef Gröne; Carsten Sticht; Marilena Marinescu; Norbert Gretz; Daniel Finke; Hugo A. Katus; Johannes Backs
- Source
- Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 1, Pp 54-62 (2019)
Journal of Cachexia, Sarcopenia and Muscle
- Subject
- EXPRESSION
0301 basic medicine
Cardiac function curve
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Geriatrics & Gerontology
Left ventricular contractility
Cardiomyopathy
FOCAL ISCHEMIA
lcsh:QM1-695
Norepinephrine (medication)
03 medical and health sciences
Medicine, General & Internal
0302 clinical medicine
Atrophy
General & Internal Medicine
Physiology (medical)
Internal medicine
Occlusion
medicine
Orthopedics and Sports Medicine
BRAIN
Ischaemic stroke
Stroke
Cardiomyocytes
Denervation
Science & Technology
CARDIOMYOPATHY
business.industry
Sham surgery
Original Articles
lcsh:Human anatomy
GAMMA
medicine.disease
NERVOUS-SYSTEM
KNOCKOUT
030104 developmental biology
030220 oncology & carcinogenesis
Cardiac dysfunction
Cardiology
HEART
Original Article
lcsh:RC925-935
business
Life Sciences & Biomedicine
medicine.drug
- Language
- ISSN
- 2190-6009
2190-5991
Background Stroke can lead to cardiac dysfunction in patients, but the mechanisms underlying the interaction between the injured brain and the heart are poorly understood. The objective of the study is to investigate the effects of experimental murine stroke on cardiac function and molecular signalling in the heart. Methods and results Mice were subjected to filament‐induced left middle cerebral artery occlusion for 30 or 60 min or sham surgery and underwent repetitive micro‐echocardiography. Left ventricular contractility was reduced early (24–72 h) but not late (2 months) after brain ischaemia. Cardiac dysfunction was accompanied by a release of high‐sensitive cardiac troponin (hsTNT (ng/ml): d1: 7.0 ± 1.0 vs. 25.0 ± 3.2*; d3: 7.3 ± 1.1 vs. 52.2 ± 16.7*; d14: 5.7 ± 0.8 vs. 5.2 ± 0.3; sham vs. 60 min. MCAO; mean ± SEM; *p