There is limited data on sex differences in renal hemodynamics and autoregulation (AR). We assessed renal vascular resistance (RVR) and renal AR in conscious male (M) and female (F) rats with intact kidneys, uninephrectomy (UNX), and UNX administered deoxycorticosterone acetate (DOCA)+salt. The susceptibility to hypertension-induced renal damage (HIRD) was also assessed in rats with UNX administered DOCA+salt. We hypothesized that M rats exhibit a lower RVR, weaker renal AR responses, and an increased susceptibility to HIRD.Sprague-Dawley rats (8-11-week-old) administered a 0.4% NaCl chow diet and water ad libitum were used. Blood pressure (BP, DSI) and renal blood flow (RBF, Transonic) were assessed in conscious rats with intact kidneys (n=12M,13F) and in rats with UNX (n=7M,8F) before and during 1 week of DOCA (3.3 mg/day s.c.) + salt (1% NaCl in drinking water). RVR was calculated as BP/RBF. Renal AR responses (fractional Δ in RBF / fractional Δ in BP) at 2.5 seconds and 20 seconds following spontaneous BP fluctuations ≥ ±5 mmHg were calculated as recently described (PMID 31792155). A 2-way ANOVA with Sidak post hoc analysis was used to assess differences among groups. Data are mean±SE, and P NIH (HL154067) and East Tennessee State University This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.