Are follicular dendritic cells really good for nothing?
- Resource Type
- Authors
- Marie H. Kosco-Vilbois
- Source
- Nature Reviews Immunology. 3:764-769
- Subject
- B-Lymphocytes
History
Antigen-Antibody Complex
Follicular dendritic cells
Antigen presentation
Receptors, Antigen, B-Cell
Germinal center
Apoptosis
Host defence
Immunological memory
Biology
Germinal Center
Computer Science Applications
Education
Cell biology
Immune system
Antigen
Immunology
Animals
Humans
Immunologic Memory
Dendritic Cells, Follicular
- Language
- ISSN
- 1474-1741
1474-1733
Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.