Introduction: Many departments in Europe treat patients with severe respiratory diseases in the respiratory intermediate care units (RICUs). Non-invasive mechanical ventilation (NIV) and high flow nasal cannula (HFNC) are the cornestone of the treatments prescribed. The aim of the present study was to describe the 7 months activity of our unit and compare the use of NIV vs HFNC. Methods: A systematic record of activity carried out between January and July 2019 was kept prospectively. The main variables were demographics, clinical data, respiratory support methods, and in-hospital mortality. Results: Of 112 patients with a mean age of 63 years admitted to the unit, 41 had do-not-intubate (DNI) orders. 41% came from the emergency department, 27% from the intensive care unit (ICU), 32% from others services. Severe hypoxemic failure (43.8%) was the main respiratory indication, respiratory acidosis was the second (24.1%) (fig1). 30.3% required NIV, 30,3% required HFNC, 12,5% alternated both systems. Rest data showed in fig2. Median length of stay was 4 days. 67% of patients were discharged to the respiratory ward; 15.3% to other wards, 2.7% required subsequent admission to the ICU, 15% died. Conclusions: In this sample, we highlight the role of HFNC that nearly equals the indications for NIV