The emission region of $\rm \gamma$-ray bursts (GRBs) is poorly constrained. The uncertainty on the size of the dissipation site spans over 4 orders of magnitude ($\rm 10^{12}-10^{17}$ cm) depending on the unknown energy composition of the GRB jets. The joint multi-band analysis from soft X-rays to high energies (up to $\rm \sim$ 1 GeV) of one of the most energetic and distant GRB 220101A (z = 4.618) allows us for an accurate distinction between prompt and early afterglow emissions. The enormous amount of energy released by GRB 220101A ($\rm E_{iso} \approx 3 \times10^{54}$ erg) and the spectral cutoff at $\rm E_{cutoff} = 85_{-26}^{+16}$ MeV observed in the prompt emission spectrum constrains the parameter space of GRB dissipation site. We put stringent constraints on the prompt emission site, requiring $\rm 700
Comment: 16 pages, 7 figures. Accepted for ApJ publication