Direct Access to Benzo[b]furans through Palladium-Catalyzed Oxidative Annulation of Phenols and Unactivated Internal Alkynes
- Resource Type
- Authors
- Akhila K. Sahoo; Malleswara Rao Kuram; M. Bhanuchandra
- Source
- Angewandte Chemie International Edition. 52:4607-4612
- Subject
- Annulation
Molecular Structure
chemistry.chemical_element
Regioselectivity
General Medicine
General Chemistry
Catalysis
chemistry.chemical_compound
Phenols
chemistry
Alkynes
Organic chemistry
Oxidation-Reduction
Palladium
Benzofurans
- Language
- ISSN
- 1433-7851
2,3-Disubstituted benzo[b]furans are prepared in one step from commercially available phenols and readily accessible unactivated internal alkynes (see scheme). This Pd-catalyzed oxidative annulation has a broad substrate scope and allows access to a wide range of benzo[b]furans.