Iron overload may contribute to brain damage that involves delayed brain atrophy, edema, and neuronal cell death as well as unfavorable outcome following ischemic stroke and intracerebral hemorrhage (ICH). This prospective study was performed to determine the association of serum ferritin level, an iron storage protein, with perihematoma edema (PHE) growth as well as in-hospital mortality and long-term clinical outcome of patients with ICH. Data was collected from patients with ICH from February 2011 to April 2012. Demographic and clinical data were recorded and serum ferritin was measured on admission. Brain CT scan was performed on admission and 72 hours later. Volume of hematoma and PHE was calculated using ABC/2 formula. Functional outcome was assessed using modified Rankin Scale. A total of 63 patients were included in this study, of those 11 (17.5%) patients died during the first 72 hours of admission. There was a significant correlation between PHE growth during first 72 hours of hospitalization and serum ferritin (P